Microdosing onderzoek

This observational study (n=38) explores the cognitive-enhancing potential of microdosing psychedelic truffles in healthy adults. It finds improved convergent and divergent thinking performance after a microdose, though fluid intelligence remains unaffected.

This survey study (n=909, 65% of which microdosed) included the Unusual Uses Tasks as a proxy for divergent creativity. They found that people who microdosed psychedelics (mostly LSD (65%) and psilocybin (28%)) were more creative (p < 0.001, r = 0.15).

This observational study (n=98) investigates the effects of microdosing psychedelics on psychological functioning over six weeks. It finds increased functioning on dosing days, reduced depression and stress, lower distractibility, increased absorption, and increased neuroticism. A second study (n=263) reveals a discrepancy between expected and reported benefits, highlighting the need for controlled research.

This is the first of a four-part study (n=24) exploring the effects of a microdose of LSD (5-20µg) on a range of measures, including mood, cognition, empathy, creativity, and physiological parameters. This part of the study found that LSD increased the pain tolerance of participants.

This is the second publication of a four-part study. It was found that a microdose (20µg) of LSD increased neuroplasticity as measured by brain-derived neurotrophic factor (BDNF) levels at 6 hours (n=24). The results are, however, ambiguous and not present at all values/times.

This is the third publication of a four-part study. The double-blind, placebo-controlled study (n=23) found that 10 µg of LSD (vs 5µg) produced psychedelic (psychotropic) effects (even more so at 20µg). The peak effects were at 2.5 hours and ended at 5 hours.

This double-blind, placebo-controlled, within-subject study (n=20) found that a microdose of LSD (up to 26μg; 3x) elicited dose-dependent subjective effects during the ‘peak’ of the experience but not at the follow-up (48 hours).

In this double-blind, placebo-controlled study (n=20), a microdose of LSD (13µg) was found to increase and decrease connectivity in various areas of the brain. One of these effects correlated positively with mood increases, but overall mood changes were variable.

This is the fourth publication on the administration of a microdose of LSD (5, 10, or 20µg). The double-blind, placebo-controlled study (n=24) found enhanced attention, slower information processing, more positive mood, and increased anxiety and confusion. Again, the results are small and ambiguous.

A placebo-controlled within-subject study including, 24 healthy participants, was conducted to assess the acute effects of three LSD doses (5, 10, and 20 mcg) on measures of cognition, mood, and subjective experience.